Approved Use for EVENITY® (romosozumab-aqqg):
EVENITY® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk of fracture, or cannot use another osteoporosis medicine ... Read More or other osteoporosis medicines did not work well. Close
Approved Use for Prolia® (denosumab):
Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine... Read More
or other osteoporosis medicines did not work well. Close
Approved Use for EVENITY® (romosozumab-aqqg):
EVENITY® is a prescription medicine used to treat osteoporosis ... Read More in women after menopause who are at high risk of fracture, or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Close
Approved Use for Prolia® (denosumab):
Prolia® is a prescription medicine used to treat osteoporosis... Read More
in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Close
For women with osteoporosis after menopause at high risk for fracture. TREATMENT

The importance of sticking with your treatment

If you’re thinking about stopping treatment, here are some postmenopausal osteoporosis (PMO) facts that may cause you to think again.

TREATMENT

The importance of sticking with your treatment

If you’re thinking about stopping treatment, here are some postmenopausal osteoporosis (PMO) facts that may cause you to think again.

Woman working on her laptop
Woman working on her laptop

Bad news, good news

First, some bad news: PMO is what’s called a progressive disease. If you don’t treat it, or if you stop your treatment, it will continue to get worse.

The good news? Bone Matters® is a support program that can help you keep moving forward. From courtesy injection reminders to help you stay on treatment, to helpful exercises, nutrition tips, and more, it's a program packed with educational information to help you along the way.

Know the risks of not treating PMO

After menopause, your body begins to lose more bone than it creates. This loss of bone density, reflected in your T-score, makes your bones more brittle, and more likely to break. And to make matters worse, if you’ve had one break, you’re 5x more likely to have another within the next year.

A slip or fall you might have bounced right back from before PMO can now impact your life in all kinds of ways you don’t want. Here are a few important facts.

Woman with a cast on her broken arm

After an initial break, you’re

5x more likely

to have another within the next year

The numbers don’t lie

Every year, 1/3 of adults over 65 will fall, and many of these falls may result in broken bones.

In fact, 2 out of 3 women with PMO at high risk for fracture will break a bone at least once in their lifetime.

PMO fractures occur most often in the spine, hip, and wrist.

Three women lounging by the pool

2 out of 3 women

with PMO at high risk for fracture

will break a bone

at least once in their lifetime

Stay on track

If you’re thinking about stopping your PMO treatment, that is not a decision to take lightly. Talk with your doctor beforehand so that you fully understand the risks involved. Stopping treatment can make your PMO worse and put you at higher risk for a break.

Nutrition and exercise are important, but treatment is critical to taking control of your PMO.

So stick with it—you’ve got this. And remember, you have the Bone Matters program to rely on for support.

More resources

Two women having a conversation

The Bone Health
Essentials

Postmenopausal osteoporosis (PMO) is often referred to as a “silent disease,” meaning you...
Woman examining an X-ray

Know more about your T-score

If you’ve been diagnosed with postmenopausal
osteoporosis,...
Two people walking

Fall prevention fundamentals

Falls can have significant consequences. Two out of
three women with...
Woman sitting outside

How to plan on reaching your goals

Writing something down is the first step toward making it happen...

Important Safety Information for EVENITY® (romosozumab-aqqg):

What is the most important information I should know about EVENITY?

EVENITY can cause serious side effects, including increased risk of having a heart attack, stroke, or death from a cardiovascular (heart or blood vessel) problem. Call your healthcare provider or get emergency help right away if you have any of these symptoms: symptoms of heart attack, which may include: chest pain or pressure; shortness of breath; feeling light-headed or dizzy; or symptoms of stroke, which may include: headache; numbness or weakness in face, arm, or legs; difficulty talking; changes in vision or loss of balance. Before you receive EVENITY, tell your healthcare provider if you have had a heart attack or stroke, especially if it has happened in the past year.

Do not receive EVENITY if you: have low blood calcium; or are allergic to romosozumab or any of the ingredients in EVENITY.

Before receiving EVENITY, tell your healthcare provider about all your medical conditions, including if you:

  • have a history of other heart or blood vessel problems
  • have low blood calcium
  • cannot take daily calcium and vitamin D
  • have kidney problems or are on kidney dialysis
  • plan to have dental surgery or teeth removed

What are the possible side effects of EVENITY?

EVENITY may cause serious side effects, including:

Serious allergic reactions have happened in people who receive EVENITY. Call your healthcare provider or go to the nearest emergency room right away if you have any symptoms of a serious allergic reaction including: rash; hives; swelling of the face, lips, mouth, tongue, or throat which may cause difficulty in swallowing or breathing.

Low calcium levels in your blood (hypocalcemia). EVENITY may lower the calcium levels in your blood. Your low blood calcium should be treated before you receive EVENITY. Call your healthcare provider if you have symptoms of low blood calcium such as: spasms, twitches, or cramps in your muscles; numbness or tingling in your fingers, toes or around your mouth.

Severe jaw bone problems (osteonecrosis) may occur. Your healthcare provider should examine your mouth before you start EVENITY and may tell you to see your dentist. Ask your healthcare provider or dentist about good mouth care.

Unusual thigh bone fractures. Symptoms of this type of fracture include new or unusual pain in your hip, groin, or thigh.

The most common side effects of EVENITY include joint pain and headaches.

These are not all the possible side effects of EVENITY. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Approved Use:

EVENITY is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk of fracture, or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.

Please see accompanying EVENITY full Prescribing Information, including Medication Guide.

Important Safety Information for Prolia® (denosumab):

What is the most important information I should know about Prolia?

If you receive Prolia, you should not receive XGEVA® (denosumab). Prolia contains the same medicine as XGEVA.

Prolia can cause serious side effects (including):

Increased risk of severe low calcium levels in your blood (hypocalcemia). Prolia may lower the calcium levels in your blood. If you have low blood calcium before you start receiving Prolia, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia. Talk to your doctor before starting Prolia. Your doctor may prescribe calcium and vitamin D to help prevent low calcium levels in your blood while you take Prolia. Take calcium and vitamin D as your doctor tells you to.

If you have advanced chronic kidney disease (may or may not be on kidney dialysis), Prolia may increase your risk for severe low calcium levels in your blood, which could result in hospitalization, life-threatening events and death. A mineral and bone disorder associated with kidney disease called chronic kidney disease-mineral bone disorder (CKD-MBD) may increase your risk for severe low calcium levels in blood. Before you start Prolia and during treatment, your doctor may need to do certain blood tests to check for CKD-MBD.

Most people with low blood calcium levels do not have symptoms, but some people may have symptoms. Call your doctor right away if you have symptoms of low blood calcium such as:

  • spasms, twitches, or cramps in your muscles
  • numbness or tingling in your fingers, toes, or around your mouth

Serious allergic reactions have happened in people who take Prolia. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.

Severe jaw bone problems (osteonecrosis) may occur. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia.

Unusual thigh bone fractures. Some people have developed unusual fractures in their thigh bone. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.

Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. Talk with your doctor before starting Prolia treatment. After your treatment with Prolia is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Do not stop, skip or delay taking Prolia without first talking with your doctor. If your Prolia treatment is stopped, talk to your doctor about other medicine that you can take.

Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia. You may need to go to the hospital for treatment.

Prolia is a medicine that may affect the ability of your body to fight infections. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.

Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.

Bone, joint, or muscle pain. Some people who take Prolia develop severe bone, joint, or muscle pain.

Do not take Prolia if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia.

Before taking Prolia, tell your doctor about all of your medical conditions, including if you:

  • Take the medicine XGEVA (denosumab)
  • Have low blood calcium
  • Cannot take daily calcium and vitamin D
  • Had parathyroid or thyroid surgery (glands located in your neck)
  • Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome)
  • Have kidney problems or are on kidney dialysis
  • Are taking medicine that can lower your blood calcium levels
  • Plan to have dental surgery or teeth removed
  • Are pregnant or plan to become pregnant
    Females who are able to become pregnant:
    • Your healthcare provider should do a pregnancy test before you start treatment with Prolia.
    • You should use an effective method of birth control (contraception) during treatment with Prolia and for at least 5 months after your last dose of Prolia.
    • Tell your doctor right away if you become pregnant while taking Prolia.
  • Are breast-feeding or plan to breast-feed

What are the possible side effects of Prolia?

It is not known if the use of Prolia over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.

These are not all the possible side effects of Prolia. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Approved Use:

Prolia is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.

Please see Prolia full Prescribing Information, including Medication Guide.

Important Safety Information for EVENITY® (romosozumab-aqqg):

What is the most important information I should know about EVENITY?

EVENITY can cause serious side effects, including increased risk of having a heart attack, stroke, or death from a cardiovascular (heart or blood vessel) problem.

EVENITY can cause serious side effects...

Important Safety Information for Prolia® (denosumab):

What is the most important information I should know about Prolia?

If you receive Prolia, you should not receive XGEVA® (denosumab). Prolia contains the same medicine as XGEVA...

If you receive Prolia, you should not receive...